Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells.
نویسندگان
چکیده
Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labelling of Annexin V. The Annexin V-BASHY conjugate maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.
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ورودعنوان ژورنال:
- Chemical communications
دوره 53 2 شماره
صفحات -
تاریخ انتشار 2016